A CD22–Shp1 phosphatase axis controls integrin β7 display and B cell function in mucosal immunity
A CD22–Shp1 phosphatase axis controls integrin β7 display and B cell function in mucosal immunity
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Author / Creator
Ballet, Romain , Brennan, Martin , Brandl, Carolin , Feng, Ningguo , Berri, Jeremy , Cheng, Julian , Ocón, Borja , Alborzian Deh Sheikh, Amin , Marki, Alex , Bi, Yuhan , Abram, Clare L. , Lowell, Clifford A. , Tsubata, Takeshi , Greenberg, Harry B. , Macauley, Matthew S. , Ley, Klaus , Nitschke, Lars and Butcher, Eugene C.
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publication information
Publisher
New York: Nature Publishing Group US
Subjects
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Scope and Contents
Contents
The integrin α
4
β
7
selectively regulates lymphocyte trafficking and adhesion in the gut and gut-associated lymphoid tissue (GALT). Here, we describe unexpected involvement of the tyrosine phosphatase Shp1 and the B cell lectin CD22 (Siglec-2) in the regulation of α
4
β
7
surface expression and gut immunity. Shp1 selectivel...
Alternative Titles
Full title
A CD22–Shp1 phosphatase axis controls integrin β7 display and B cell function in mucosal immunity
Authors, Artists and Contributors
Author / Creator
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7116842
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7116842
Other Identifiers
ISSN
1529-2908
E-ISSN
1529-2916
DOI
10.1038/s41590-021-00862-z
