Molecular bases for HOIPINs-mediated inhibition of LUBAC and innate immune responses
Molecular bases for HOIPINs-mediated inhibition of LUBAC and innate immune responses
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Author / Creator
Oikawa, Daisuke , Sato, Yusuke , Ohtake, Fumiaki , Komakura, Keidai , Hanada, Kazuki , Sugawara, Koji , Terawaki, Seigo , Mizukami, Yukari , Phuong, Hoang T. , Iio, Kiyosei , Obika, Shingo , Fukushi, Masaya , Irie, Takashi , Tsuruta, Daisuke , Sakamoto, Shinji , Tanaka, Keiji , Saeki, Yasushi , Fukai, Shuya and Tokunaga, Fuminori
Publisher
London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Contents
The NF-κB and interferon antiviral signaling pathways play pivotal roles in inflammatory and innate immune responses. The LUBAC ubiquitin ligase complex, composed of the HOIP, HOIL-1L, and SHARPIN subunits, activates the canonical NF-κB pathway through Met1-linked linear ubiquitination. We identified small-molecule chemical inhibitors of LUBAC, HOI...
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Full title
Molecular bases for HOIPINs-mediated inhibition of LUBAC and innate immune responses
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7125101
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7125101
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ISSN
2399-3642
E-ISSN
2399-3642
DOI
10.1038/s42003-020-0882-8
