Comparative lipidomics of 5-Fluorouracil–sensitive and –resistant colorectal cancer cells reveals al...
Comparative lipidomics of 5-Fluorouracil–sensitive and –resistant colorectal cancer cells reveals altered sphingomyelin and ceramide controlled by acid sphingomyelinase (SMPD1)
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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5-Fluorouracil (5-FU) is a chemotherapeutic drug widely used to treat colorectal cancer. 5-FU is known to gradually lose its efficacy in treating colorectal cancer following the acquisition of resistance. We investigated the mechanism of 5-FU resistance using comprehensive lipidomic approaches. We performed lipidomic analysis on 5-FU–resistant (DLD...
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Comparative lipidomics of 5-Fluorouracil–sensitive and –resistant colorectal cancer cells reveals altered sphingomyelin and ceramide controlled by acid sphingomyelinase (SMPD1)
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7145850
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7145850
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2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-020-62823-0
