O-GlcNAcylation regulates the methionine cycle to promote pluripotency of stem cells
O-GlcNAcylation regulates the methionine cycle to promote pluripotency of stem cells
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Author / Creator
Zhu, Qiang , Cheng, Xuejun , Cheng, Yaxian , Chen, Junchen , Xu, Huan , Gao, Yuntao , Duan, Xiaotao , Ji, Junfeng , Li, Xuekun and Yi, Wen
Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publication information
Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
Methionine metabolism is critical for the maintenance of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) pluripotency. However, little is known about the regulation of the methionine cycle to sustain ESC pluripotency. Here, we show that adenosylhomocysteinase (AHCY), an important enzyme in the methionine cycle, is critical fo...
Alternative Titles
Full title
O-GlcNAcylation regulates the methionine cycle to promote pluripotency of stem cells
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7148567
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7148567
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1915582117
