Targeting the cyclin-dependent kinase 5 in metastatic melanoma
Targeting the cyclin-dependent kinase 5 in metastatic melanoma
About this item
Full title
Author / Creator
Sharma, Samanta , Zhang, Tian , Michowski, Wojciech , Rebecca, Vito W. , Xiao, Min , Ferretti, Roberta , Suski, Jan M. , Bronson, Roderick T. , Paulo, Joao A. , Frederick, Dennie , Fassl, Anne , Boland, Genevieve M. , Geng, Yan , Lees, Jacqueline A. , Medema, Rene H. , Herlyn, Meenhard , Gygi, Steven P. and Sicinski, Piotr
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
The cyclin-dependent kinase 5 (CDK5), originally described as a neuronal-specific kinase, is also frequently activated in human cancers. Using conditional CDK5 knockout mice and a mouse model of highly metastatic melanoma, we found that CDK5 is dispensable for the growth of primary tumors. However, we observed that ablation of CDK5 completely abrog...
Alternative Titles
Full title
Targeting the cyclin-dependent kinase 5 in metastatic melanoma
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7149478
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7149478
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1912617117
