Imipridone Anticancer Compounds Ectopically Activate the ClpP Protease and Represent a New Scaffold...
Imipridone Anticancer Compounds Ectopically Activate the ClpP Protease and Represent a New Scaffold for Antibiotic Development
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Publisher
United States: Oxford University Press
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Language
English
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Publisher
United States: Oxford University Press
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Abstract
The imipridones ONC201 and ONC212 selectively kill cancer cells and have been ascribed multiple mechanisms-of-action. Genome-wide CRISPR knockout screens revealed that loss of the mitochondrial proteases CLPP and MIPEP confer strong resistance to both compounds...
Systematic genetic interaction profiles can reveal the mechanisms-of-a...
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Full title
Imipridone Anticancer Compounds Ectopically Activate the ClpP Protease and Represent a New Scaffold for Antibiotic Development
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7153937
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7153937
Other Identifiers
ISSN
1943-2631,0016-6731
E-ISSN
1943-2631
DOI
10.1534/genetics.119.302851
