Phase 1 study of the pan-HER inhibitor dacomitinib plus the MEK1/2 inhibitor PD-0325901 in patients...
Phase 1 study of the pan-HER inhibitor dacomitinib plus the MEK1/2 inhibitor PD-0325901 in patients with KRAS-mutation-positive colorectal, non-small-cell lung and pancreatic cancer
About this item
Full title
Author / Creator
van Geel, Robin M. J. M. , van Brummelen, Emilie M. J. , Eskens, Ferry A. L. M. , Huijberts, Sanne C. F. A. , de Vos, Filip Y. F. L. , Lolkema, Martijn P. J. K. , Devriese, Lot A. , Opdam, Frans L. , Marchetti, Serena , Steeghs, Neeltje , Monkhorst, Kim , Thijssen, Bas , Rosing, Hilde , Huitema, Alwin D. R. , Beijnen, Jos H. , Bernards, René and Schellens, Jan H. M.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Background
Mutations in
KRAS
result in a constitutively activated MAPK pathway. In
KRAS
-mutant tumours existing treatment options, e.g. MEK inhibition, have limited efficacy due to resistance through feedback activation of epidermal growth factor receptors (HER).
Methods
In this Phase 1 study, the pan-HER inhibitor dacomitinib...
Alternative Titles
Full title
Phase 1 study of the pan-HER inhibitor dacomitinib plus the MEK1/2 inhibitor PD-0325901 in patients with KRAS-mutation-positive colorectal, non-small-cell lung and pancreatic cancer
Authors, Artists and Contributors
Author / Creator
van Brummelen, Emilie M. J.
Eskens, Ferry A. L. M.
Huijberts, Sanne C. F. A.
de Vos, Filip Y. F. L.
Lolkema, Martijn P. J. K.
Devriese, Lot A.
Opdam, Frans L.
Marchetti, Serena
Steeghs, Neeltje
Monkhorst, Kim
Thijssen, Bas
Rosing, Hilde
Huitema, Alwin D. R.
Beijnen, Jos H.
Bernards, René
Schellens, Jan H. M.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7156736
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7156736
Other Identifiers
ISSN
0007-0920
E-ISSN
1532-1827
DOI
10.1038/s41416-020-0776-z
