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Nonclassical nuclear localization signals mediate nuclear import of CIRBP

Nonclassical nuclear localization signals mediate nuclear import of CIRBP

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7165476

Nonclassical nuclear localization signals mediate nuclear import of CIRBP

About this item

Full title

Nonclassical nuclear localization signals mediate nuclear import of CIRBP

Publisher

United States: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2020-04, Vol.117 (15), p.8503-8514

Language

English

Formats

Publication information

Publisher

United States: National Academy of Sciences

More information

Scope and Contents

Contents

The specific interaction of importins with nuclear localization signals (NLSs) of cargo proteins not only mediates nuclear import but also, prevents their aberrant phase separation and stress granule recruitment in the cytoplasm. The importin Transportin-1 (TNPO1) plays a key role in the (patho-)physiology of both processes. Here, we report that bo...

Alternative Titles

Full title

Nonclassical nuclear localization signals mediate nuclear import of CIRBP

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7165476

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7165476

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

DOI

10.1073/pnas.1918944117

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