A chimeric poxvirus with J2R (thymidine kinase) deletion shows safety and anti-tumor activity in lun...
A chimeric poxvirus with J2R (thymidine kinase) deletion shows safety and anti-tumor activity in lung cancer models
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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Oncolytic viruses have shown excellent safety profiles in preclinical and clinical studies; however, in most cases therapeutic benefits have been modest. We have previously reported the generation of a chimeric poxvirus (CF33), with significantly improved oncolytic characteristics, through chimerization among different poxviruses. Here we report th...
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A chimeric poxvirus with J2R (thymidine kinase) deletion shows safety and anti-tumor activity in lung cancer models
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7170804
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7170804
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ISSN
0929-1903
E-ISSN
1476-5500
DOI
10.1038/s41417-019-0114-x
