Transient receptor potential ion channel TRPM2 promotes AML proliferation and survival through modul...
Transient receptor potential ion channel TRPM2 promotes AML proliferation and survival through modulation of mitochondrial function, ROS, and autophagy
About this item
Full title
Author / Creator
Chen, Shu-jen , Bao, Lei , Keefer, Kerry , Shanmughapriya, Santhanam , Chen, Longgui , Lee, John , Wang, JuFang , Zhang, Xue-Qian , Hirschler-Laszkiewicz, Iwona , Merali, Salim , Merali, Carmen , Imamura, Yuka , Dovat, Sinisa , Madesh, Muniswamy , Cheung, Joseph Y. , Wang, Hong-Gang and Miller, Barbara A.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
Subjects
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Scope and Contents
Contents
Transient receptor potential melastatin 2 (TRPM2) ion channel has an essential function in maintaining cell survival following oxidant injury. Here, we show that TRPM2 is highly expressed in acute myeloid leukemia (AML). The role of TRPM2 in AML was studied following depletion with CRISPR/Cas9 technology in U937 cells. In in vitro experiments and i...
Alternative Titles
Full title
Transient receptor potential ion channel TRPM2 promotes AML proliferation and survival through modulation of mitochondrial function, ROS, and autophagy
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7170900
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7170900
Other Identifiers
ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/s41419-020-2454-8
