A necroptotic-independent function of MLKL in regulating endothelial cell adhesion molecule expressi...
A necroptotic-independent function of MLKL in regulating endothelial cell adhesion molecule expression
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Author / Creator
Dai, Jialin , Zhang, Chonghe , Guo, Lin , He, Hao , Jiang, Kai , Huang, Yingying , Zhang, Xixi , Zhang, Haibing , Wei, Wu , Zhang, Yaoyang , Lu, Lihua and Hu, Junhao
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Mixed-lineage kinase domain-like protein (MLKL) is known as the terminal executor of necroptosis. However, its function outside of necroptosis is still not clear. Herein, we demonstrate that MLKL promotes vascular inflammation by regulating the expression of adhesion molecules ICAM1, VCAM1, and E-selectin in endothelial cells (EC). MLKL deficiency...
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Full title
A necroptotic-independent function of MLKL in regulating endothelial cell adhesion molecule expression
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7181788
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7181788
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ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/s41419-020-2483-3
