SIRT1 in forebrain excitatory neurons produces sexually dimorphic effects on depression-related beha...
SIRT1 in forebrain excitatory neurons produces sexually dimorphic effects on depression-related behaviors and modulates neuronal excitability and synaptic transmission in the medial prefrontal cortex
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Author / Creator
Lei, Yun , Wang, Jiangong , Wang, Dan , Li, Chen , Liu, Bin , Fang, Xing , You, Jingjing , Guo, Ming and Lu, Xin-Yun
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Contents
Sirtuin 1 (SIRT1), an NAD
+
-dependent deacetylase, is a key regulator of cellular metabolism. Recent genome-wide association studies identified genetic variants of SIRT1 linked to major depressive disorders. SIRT1 is widely expressed in the brain; however, neuronal substrates that mediate SIRT1 action on depressive behaviors remain largely u...
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Full title
SIRT1 in forebrain excitatory neurons produces sexually dimorphic effects on depression-related behaviors and modulates neuronal excitability and synaptic transmission in the medial prefrontal cortex
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7192847
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7192847
Other Identifiers
ISSN
1359-4184
E-ISSN
1476-5578
DOI
10.1038/s41380-019-0352-1
