Seasonal changes in NRF2 antioxidant pathway regulates winter depression-like behavior
Seasonal changes in NRF2 antioxidant pathway regulates winter depression-like behavior
About this item
Full title
Author / Creator
Nakayama, Tomoya , Okimura, Kousuke , Shen, Jiachen , Guh, Ying-Jey , Tamai, T. Katherine , Shimada, Akiko , Minou, Souta , Okushi, Yuki , Shimmura, Tsuyoshi , Furukawa, Yuko , Kadofusa, Naoya , Sato, Ayato , Nishimura, Toshiya , Tanaka, Minoru , Nakayama, Kei , Shiina, Nobuyuki , Yamamoto, Naoyuki , Loudon, Andrew S. , Nishiwaki-Ohkawa, Taeko , Shinomiya, Ai , Nabeshima, Toshitaka , Nakane, Yusuke and Yoshimura, Takashi
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
Seasonal changes in the environment lead to depression-like behaviors in humans and animals. The underlying mechanisms, however, are unknown. We observed decreased sociability and increased anxiety-like behavior in medaka fish exposed to winter-like conditions. Whole brain metabolomic analysis revealed seasonal changes in 68 metabolites, including...
Alternative Titles
Full title
Seasonal changes in NRF2 antioxidant pathway regulates winter depression-like behavior
Authors, Artists and Contributors
Author / Creator
Okimura, Kousuke
Shen, Jiachen
Guh, Ying-Jey
Tamai, T. Katherine
Shimada, Akiko
Minou, Souta
Okushi, Yuki
Shimmura, Tsuyoshi
Furukawa, Yuko
Kadofusa, Naoya
Sato, Ayato
Nishimura, Toshiya
Tanaka, Minoru
Nakayama, Kei
Shiina, Nobuyuki
Yamamoto, Naoyuki
Loudon, Andrew S.
Nishiwaki-Ohkawa, Taeko
Shinomiya, Ai
Nabeshima, Toshitaka
Nakane, Yusuke
Yoshimura, Takashi
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7196813
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7196813
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.2000278117
