Tetanus Toxin cis -Loop Contributes to Light-Chain Translocation
Tetanus Toxin cis -Loop Contributes to Light-Chain Translocation
About this item
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Author / Creator
Publisher
United States: American Society for Microbiology
Journal title
Language
English
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Publisher
United States: American Society for Microbiology
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Scope and Contents
Contents
How protein toxins translocate their catalytic domain across a cell membrane is the least understood step in toxin action. This study utilized a reporter, β-lactamase, that was genetically fused to full-length, nontoxic tetanus toxin (βlac-TT) in discovery-based live-cell assays to study LC translocation. Directed mutagenesis identified a role for...
Alternative Titles
Full title
Tetanus Toxin cis -Loop Contributes to Light-Chain Translocation
Authors, Artists and Contributors
Author / Creator
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7203457
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7203457
Other Identifiers
ISSN
2379-5042
E-ISSN
2379-5042
DOI
10.1128/mSphere.00244-20
