LZTR1 facilitates polyubiquitination and degradation of RAS-GTPases
LZTR1 facilitates polyubiquitination and degradation of RAS-GTPases
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Leucine zipper-like transcriptional regulator 1 (LZTR1) encodes a member of the BTB-Kelch superfamily, which interacts with the Cullin3 (CUL3)-based E3 ubiquitin ligase complex. Mutations in
LZTR1
have been identified in glioblastoma, schwannomatosis, and Noonan syndrome. However, the functional role of LZTR1 in carcinogenesis or human develo...
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Full title
LZTR1 facilitates polyubiquitination and degradation of RAS-GTPases
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7206011
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7206011
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ISSN
1350-9047
E-ISSN
1476-5403
DOI
10.1038/s41418-019-0395-5
