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APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline

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APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7250000

APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline

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Publication information

Publisher

London: Nature Publishing Group UK

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Subjects and topics

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Scope and Contents

Contents

Vascular contributions to dementia and Alzheimer’s disease are increasingly recognized
1
–
6
. Recent studies have suggested that breakdown of the blood–brain barrier (BBB) is an early biomarker of human cognitive dysfunction
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, including the early clinical stages of Alzheimer’s disease
5
,
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–
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. The E4 varia...

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Full title

APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline

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Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7250000

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7250000

Other Identifiers

ISSN

0028-0836

E-ISSN

1476-4687

DOI

10.1038/s41586-020-2247-3

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