AMOTL1 enhances YAP1 stability and promotes YAP1-driven gastric oncogenesis
AMOTL1 enhances YAP1 stability and promotes YAP1-driven gastric oncogenesis
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Hippo signaling functions to limit cellular growth, but the aberrant nuclear accumulation of its downstream YAP1 leads to carcinogenesis. YAP1/TEAD complex activates the oncogenic downstream transcription, such as CTGF and c-Myc. How YAP1 is protected in the cytoplasm from ubiquitin-mediated degradation remains elusive. In this study, a member of A...
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Full title
AMOTL1 enhances YAP1 stability and promotes YAP1-driven gastric oncogenesis
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7253359
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7253359
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ISSN
0950-9232
E-ISSN
1476-5594
DOI
10.1038/s41388-020-1293-5
