Vasopressin receptor 2 mutations in the nephrogenic syndrome of inappropriate antidiuresis show diff...
Vasopressin receptor 2 mutations in the nephrogenic syndrome of inappropriate antidiuresis show different mechanisms of constitutive activation for G protein coupled receptors
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Vasopressin receptor 2 (V2R) mutations causing the nephrogenic syndrome of inappropriate antidiuresis (NSIAD) can generate two constitutively active receptor phenotypes. One type results from residue substitutions in several V2R domains and is sensitive to vaptan inverse agonists. The other is only caused by Arg 137 replacements and is vaptan resis...
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Vasopressin receptor 2 mutations in the nephrogenic syndrome of inappropriate antidiuresis show different mechanisms of constitutive activation for G protein coupled receptors
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7272623
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7272623
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-020-65996-w
