Transcriptional profiling identifies an androgen receptor activity-low, stemness program associated...
Transcriptional profiling identifies an androgen receptor activity-low, stemness program associated with enzalutamide resistance
About this item
Full title
Author / Creator
Alumkal, Joshi J. , Sun, Duanchen , Lu, Eric , Beer, Tomasz M. , Thomas, George V. , Latour, Emile , Aggarwal, Rahul , Cetnar, Jeremy , Ryan, Charles J. , Tabatabaei, Shaadi , Bailey, Shawna , Turina, Claire B. , Quigley, David A. , Guan, Xiangnan , Foye, Adam , Youngren, Jack F. , Urrutia, Joshua , Huang, Jiaoti , Weinstein, Alana S. , Friedl, Verena , Rettig, Matthew , Reiter, Robert E. , Spratt, Daniel E. , Gleave, Martin , Evans, Christopher P. , Stuart, Joshua M. , Chen, Yiyi , Feng, Felix Y. , Small, Eric J. , Witte, Owen N. and Xia, Zheng
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
The androgen receptor (AR) antagonist enzalutamide is one of the principal treatments for men with castration-resistant prostate cancer (CRPC). However, not all patients respond, and resistance mechanisms are largely unknown. We hypothesized that genomic and transcriptional features from metastatic CRPC biopsies prior to treatment would be predicti...
Alternative Titles
Full title
Transcriptional profiling identifies an androgen receptor activity-low, stemness program associated with enzalutamide resistance
Authors, Artists and Contributors
Author / Creator
Sun, Duanchen
Lu, Eric
Beer, Tomasz M.
Thomas, George V.
Latour, Emile
Aggarwal, Rahul
Cetnar, Jeremy
Ryan, Charles J.
Tabatabaei, Shaadi
Bailey, Shawna
Turina, Claire B.
Quigley, David A.
Guan, Xiangnan
Foye, Adam
Youngren, Jack F.
Urrutia, Joshua
Huang, Jiaoti
Weinstein, Alana S.
Friedl, Verena
Rettig, Matthew
Reiter, Robert E.
Spratt, Daniel E.
Gleave, Martin
Evans, Christopher P.
Stuart, Joshua M.
Chen, Yiyi
Feng, Felix Y.
Small, Eric J.
Witte, Owen N.
Xia, Zheng
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7275746
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7275746
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1922207117
