Oncometabolites suppress DNA repair by disrupting local chromatin signalling
Oncometabolites suppress DNA repair by disrupting local chromatin signalling
About this item
Full title
Author / Creator
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Deregulation of metabolism and disruption of genome integrity are hallmarks of cancer
1
. Increased levels of the metabolites 2-hydroxyglutarate, succinate and fumarate occur in human malignancies owing to somatic mutations in the isocitrate dehydrogenase-1 or -2 (
IDH1
or
IDH2
) genes, or germline mutations in the fumarate hydrat...
Alternative Titles
Full title
Oncometabolites suppress DNA repair by disrupting local chromatin signalling
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7319896
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7319896
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-020-2363-0
