NLRP3 inflammasome activation drives tau pathology
NLRP3 inflammasome activation drives tau pathology
About this item
Full title
Author / Creator
Ising, Christina , Venegas, Carmen , Zhang, Shuangshuang , Scheiblich, Hannah , Schmidt, Susanne V. , Vieira-Saecker, Ana , Schwartz, Stephanie , Albasset, Shadi , McManus, Róisín M. , Tejera, Dario , Griep, Angelika , Santarelli, Francesco , Brosseron, Frederic , Opitz, Sabine , Stunden, James , Merten, Maximilian , Kayed, Rakez , Golenbock, Douglas T. , Blum, David , Latz, Eicke , Buée, Luc and Heneka, Michael T.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Alzheimer’s disease is characterized by the accumulation of amyloid-beta in plaques, aggregation of hyperphosphorylated tau in neurofibrillary tangles and neuroinflammation, together resulting in neurodegeneration and cognitive decline
1
. The NLRP3 inflammasome assembles inside of microglia on activation, leading to increased cleavage and ac...
Alternative Titles
Full title
NLRP3 inflammasome activation drives tau pathology
Authors, Artists and Contributors
Author / Creator
Venegas, Carmen
Zhang, Shuangshuang
Scheiblich, Hannah
Schmidt, Susanne V.
Vieira-Saecker, Ana
Schwartz, Stephanie
Albasset, Shadi
McManus, Róisín M.
Tejera, Dario
Griep, Angelika
Santarelli, Francesco
Brosseron, Frederic
Opitz, Sabine
Stunden, James
Merten, Maximilian
Kayed, Rakez
Golenbock, Douglas T.
Blum, David
Latz, Eicke
Buée, Luc
Heneka, Michael T.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7324015
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7324015
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-019-1769-z
