Caspase-11–mediated enteric neuronal pyroptosis underlies Western diet–induced colonic dysmotility
Caspase-11–mediated enteric neuronal pyroptosis underlies Western diet–induced colonic dysmotility
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Author / Creator
Ye, Lan , Li, Ge , Goebel, Anna , Raju, Abhinav V. , Kong, Feng , Lv, Yanfei , Li, Kailin , Zhu, Yuanjun , Raja, Shreya , He, Peijian , Li, Fang , Mwangi, Simon Musyoka , Hu, Wenhui and Srinivasan, Shanthi
Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
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Publisher
United States: American Society for Clinical Investigation
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Scope and Contents
Contents
Enteric neuronal degeneration, as seen in inflammatory bowel disease, obesity, and diabetes, can lead to gastrointestinal dysmotility. Pyroptosis is a novel form of programmed cell death but little is known about its role in enteric neuronal degeneration. We observed higher levels of cleaved caspase-1, a marker of pyroptosis, in myenteric ganglia o...
Alternative Titles
Full title
Caspase-11–mediated enteric neuronal pyroptosis underlies Western diet–induced colonic dysmotility
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7324173
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7324173
Other Identifiers
ISSN
0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI130176
