Formaldehyde treatment of proteins enhances proteolytic degradation by the endo-lysosomal protease c...
Formaldehyde treatment of proteins enhances proteolytic degradation by the endo-lysosomal protease cathepsin S
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Enzymatic degradation of protein antigens by endo-lysosomal proteases in antigen-presenting cells is crucial for achieving cellular immunity. Structural changes caused by vaccine production process steps, such as formaldehyde inactivation, could affect the sensitivity of the antigen to lysosomal proteases. The aim of this study was to assess the ef...
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Full title
Formaldehyde treatment of proteins enhances proteolytic degradation by the endo-lysosomal protease cathepsin S
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7360561
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7360561
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-020-68248-z
