Receptor-interacting protein kinase 1 (RIPK1) as a therapeutic target
Receptor-interacting protein kinase 1 (RIPK1) as a therapeutic target
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) is a key mediator of cell death and inflammation. The unique hydrophobic pocket in the allosteric regulatory domain of RIPK1 has enabled the development of highly selective small-molecule inhibitors of its kinase activity, which have demonstrated safety in preclinical models and clinica...
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Full title
Receptor-interacting protein kinase 1 (RIPK1) as a therapeutic target
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7362612
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7362612
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ISSN
1474-1776
E-ISSN
1474-1784
DOI
10.1038/s41573-020-0071-y
