JNK-mediated disruption of bile acid homeostasis promotes intrahepatic cholangiocarcinoma
JNK-mediated disruption of bile acid homeostasis promotes intrahepatic cholangiocarcinoma
About this item
Full title
Author / Creator
Manieri, Elisa , Folgueira, Cintia , Rodríguez, María Elena , Leiva-Vega, Luis , Esteban-Lafuente, Laura , Chen, Chaobo , Cubero, Francisco Javier , Barrett, Tamera , Cavanagh-Kyros, Julie , Seruggia, Davide , Rosell, Alejandro , Sanchez-Cabo, Fátima , Gómez, Manuel Jose , Monte, Maria J. , Marin, Jose J. G. , Davis, Roger J. , Mora, Alfonso and Sabio, Guadalupe
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
Metabolic stress causes activation of the cJun NH₂-terminal kinase (JNK) signal transduction pathway. It is established that one consequence of JNK activation is the development of insulin resistance and hepatic steatosis through inhibition of the transcription factor PPARα. Indeed, JNK1/2 deficiency in hepatocytes protects against the development...
Alternative Titles
Full title
JNK-mediated disruption of bile acid homeostasis promotes intrahepatic cholangiocarcinoma
Authors, Artists and Contributors
Author / Creator
Folgueira, Cintia
Rodríguez, María Elena
Leiva-Vega, Luis
Esteban-Lafuente, Laura
Chen, Chaobo
Cubero, Francisco Javier
Barrett, Tamera
Cavanagh-Kyros, Julie
Seruggia, Davide
Rosell, Alejandro
Sanchez-Cabo, Fátima
Gómez, Manuel Jose
Monte, Maria J.
Marin, Jose J. G.
Davis, Roger J.
Mora, Alfonso
Sabio, Guadalupe
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7368313
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7368313
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.2002672117
