CRISPR screens in cancer spheroids identify 3D growth-specific vulnerabilities
CRISPR screens in cancer spheroids identify 3D growth-specific vulnerabilities
About this item
Full title
Author / Creator
Han, Kyuho , Pierce, Sarah E. , Li, Amy , Spees, Kaitlyn , Anderson, Gray R. , Seoane, Jose A. , Lo, Yuan-Hung , Dubreuil, Michael , Olivas, Micah , Kamber, Roarke A. , Wainberg, Michael , Kostyrko, Kaja , Kelly, Marcus R. , Yousefi, Maryam , Simpkins, Scott W. , Yao, David , Lee, Keonil , Kuo, Calvin J. , Jackson, Peter K. , Sweet-Cordero, Alejandro , Kundaje, Anshul , Gentles, Andrew J. , Curtis, Christina , Winslow, Monte M. and Bassik, Michael C.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Cancer genomics studies have identified thousands of putative cancer driver genes
1
. Development of high-throughput and accurate models to define the functions of these genes is a major challenge. Here we devised a scalable cancer-spheroid model and performed genome-wide CRISPR screens in 2D monolayers and 3D lung-cancer spheroids. CRISPR ph...
Alternative Titles
Full title
CRISPR screens in cancer spheroids identify 3D growth-specific vulnerabilities
Authors, Artists and Contributors
Author / Creator
Pierce, Sarah E.
Li, Amy
Spees, Kaitlyn
Anderson, Gray R.
Seoane, Jose A.
Lo, Yuan-Hung
Dubreuil, Michael
Olivas, Micah
Kamber, Roarke A.
Wainberg, Michael
Kostyrko, Kaja
Kelly, Marcus R.
Yousefi, Maryam
Simpkins, Scott W.
Yao, David
Lee, Keonil
Kuo, Calvin J.
Jackson, Peter K.
Sweet-Cordero, Alejandro
Kundaje, Anshul
Gentles, Andrew J.
Curtis, Christina
Winslow, Monte M.
Bassik, Michael C.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7368463
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7368463
Other Identifiers
ISSN
0028-0836,1476-4687
E-ISSN
1476-4687
DOI
10.1038/s41586-020-2099-x
