Squamous differentiation requires G2/mitosis slippage to avoid apoptosis
Squamous differentiation requires G2/mitosis slippage to avoid apoptosis
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The cellular mechanisms controlling cell fate in self-renewal tissues remain unclear. Cell cycle failure often leads to an apoptosis anti-oncogenic response. We have inactivated Cdk1 or Polo-like-1 kinases, essential targets of the mitotic checkpoints, in the epithelia of skin and oral mucosa. Here, we show that inactivation of the mitotic kinases...
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Full title
Squamous differentiation requires G2/mitosis slippage to avoid apoptosis
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7370216
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7370216
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ISSN
1350-9047
E-ISSN
1476-5403
DOI
10.1038/s41418-020-0515-2
