The lipogenic LXR-SREBF1 signaling pathway controls cancer cell DNA repair and apoptosis and is a vu...
The lipogenic LXR-SREBF1 signaling pathway controls cancer cell DNA repair and apoptosis and is a vulnerable point of malignant tumors for cancer therapy
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Author / Creator
Yang, Bo , Zhang, Bin , Cao, Zhifei , Xu, Xingdong , Huo, Zihe , Zhang, Pan , Xiang, Shufen , Zhao, Zhe , Lv, Chunping , Meng, Mei , Zhang, Gaochuan , Dong, Liang , Shi, Shucheng , Yang, Lan and Zhou, Quansheng
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Cancer cells are defective in DNA repair, so they experience increased DNA strand breaks, genome instability, gene mutagenesis, and tumorigenicity; however, multiple classic DNA repair genes and pathways are strongly activated in malignant tumor cells to compensate for the DNA repair deficiency and gain an apoptosis resistance. The mechanisms under...
Alternative Titles
Full title
The lipogenic LXR-SREBF1 signaling pathway controls cancer cell DNA repair and apoptosis and is a vulnerable point of malignant tumors for cancer therapy
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7370224
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7370224
Other Identifiers
ISSN
1350-9047
E-ISSN
1476-5403
DOI
10.1038/s41418-020-0514-3
