Insulin2Q104del (Kuma) mutant mice develop diabetes with dominant inheritance
Insulin2Q104del (Kuma) mutant mice develop diabetes with dominant inheritance
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Insulin gene mutations have been identified to cause monogenic diabetes, and most of which developed permanent neonatal diabetes at young ages before 6 months of age in humans. To establish an animal model of permanent diabetes, we performed genome editing using the CRISPR/Cas9 system. We generated a novel Kuma mutant mice with p.Q104del in the
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Full title
Insulin2Q104del (Kuma) mutant mice develop diabetes with dominant inheritance
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7376009
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7376009
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-020-68987-z
