Human SNORA31 variations impair cortical neuron-intrinsic immunity to HSV-1 and underlie herpes simp...
Human SNORA31 variations impair cortical neuron-intrinsic immunity to HSV-1 and underlie herpes simplex encephalitis
About this item
Full title
Author / Creator
Lafaille, Fabien G. , Harschnitz, Oliver , Lee, Yoon Seung , Zhang, Peng , Hasek, Mary L. , Kerner, Gaspard , Itan, Yuval , Ewaleifoh, Osefame , Rapaport, Franck , Carlile, Thomas M. , Carter-Timofte, Madalina E. , Paquet, Dominik , Dobbs, Kerry , Zimmer, Bastian , Gao, Daxing , Rojas-Duran, Maria F. , Kwart, Dylan , Rattina, Vimel , Ciancanelli, Michael J. , McAlpine, Jessica L. , Lorenzo, Lazaro , Boucherit, Soraya , Rozenberg, Flore , Halwani, Rabih , Henry, Benoit , Amenzoui, Naima , Alsum, Zobaida , Marques, Laura , Church, Joseph A. , Al-Muhsen, Saleh , Tardieu, Marc , Bousfiha, Ahmed Aziz , Paludan, Søren R. , Mogensen, Trine Hyrup , Quintana-Murci, Lluis , Tessier-Lavigne, Marc , Smith, Gregory A. , Notarangelo, Luigi D. , Studer, Lorenz , Gilbert, Wendy , Abel, Laurent , Casanova, Jean-Laurent and Zhang, Shen-Ying
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Herpes simplex virus-1 (HSV-1) encephalitis (HSE) is typically sporadic. Inborn errors of TLR3- and DBR1-mediated central nervous system cell-intrinsic immunity can account for forebrain and brainstem HSE, respectively. We report five unrelated patients with forebrain HSE, each heterozygous for one of four rare variants of
SNORA31
, encoding...
Alternative Titles
Full title
Human SNORA31 variations impair cortical neuron-intrinsic immunity to HSV-1 and underlie herpes simplex encephalitis
Authors, Artists and Contributors
Author / Creator
Harschnitz, Oliver
Lee, Yoon Seung
Zhang, Peng
Hasek, Mary L.
Kerner, Gaspard
Itan, Yuval
Ewaleifoh, Osefame
Rapaport, Franck
Carlile, Thomas M.
Carter-Timofte, Madalina E.
Paquet, Dominik
Dobbs, Kerry
Zimmer, Bastian
Gao, Daxing
Rojas-Duran, Maria F.
Kwart, Dylan
Rattina, Vimel
Ciancanelli, Michael J.
McAlpine, Jessica L.
Lorenzo, Lazaro
Boucherit, Soraya
Rozenberg, Flore
Halwani, Rabih
Henry, Benoit
Amenzoui, Naima
Alsum, Zobaida
Marques, Laura
Church, Joseph A.
Al-Muhsen, Saleh
Tardieu, Marc
Bousfiha, Ahmed Aziz
Paludan, Søren R.
Mogensen, Trine Hyrup
Quintana-Murci, Lluis
Tessier-Lavigne, Marc
Smith, Gregory A.
Notarangelo, Luigi D.
Studer, Lorenz
Gilbert, Wendy
Abel, Laurent
Casanova, Jean-Laurent
Zhang, Shen-Ying
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7376819
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7376819
Other Identifiers
ISSN
1078-8956,1546-170X
E-ISSN
1546-170X,1744-7933
DOI
10.1038/s41591-019-0672-3
