Tankyrase inhibition ameliorates lipid disorder via suppression of PGC-1α PARylation in db/db mice
Tankyrase inhibition ameliorates lipid disorder via suppression of PGC-1α PARylation in db/db mice
About this item
Full title
Author / Creator
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Objective
Human TNKS, encoding tankyrase 1 (TNKS1), localizes to a susceptibility locus for obesity and type 2 diabetes mellitus (T2DM). Here, we addressed the therapeutic potential of G007-LK, a TNKS-specific inhibitor, for obesity and T2DM.
Methods
We administered G007-LK to diabetic
db/db
mice and measured the impact on body weigh...
Alternative Titles
Full title
Tankyrase inhibition ameliorates lipid disorder via suppression of PGC-1α PARylation in db/db mice
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7381423
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7381423
Other Identifiers
ISSN
0307-0565
E-ISSN
1476-5497
DOI
10.1038/s41366-020-0573-z
