Dianhydrogalactitol synergizes with topoisomerase poisons to overcome DNA repair activity in tumor c...
Dianhydrogalactitol synergizes with topoisomerase poisons to overcome DNA repair activity in tumor cells
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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1,2:5,6-Dianhydrogalactitol (DAG) is a bi-functional DNA-targeting agent currently in phase II clinical trial for treatment of temozolomide-resistant glioblastoma (GBM). In the present study, we investigated the cytotoxic activity of DAG alone or in combination with common chemotherapy agents in GBM and prostate cancer (PCa) cells, and determined t...
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Full title
Dianhydrogalactitol synergizes with topoisomerase poisons to overcome DNA repair activity in tumor cells
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7381652
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7381652
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ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/s41419-020-02780-8
