Genomic discovery of an evolutionarily programmed modality for small-molecule targeting of an intrac...
Genomic discovery of an evolutionarily programmed modality for small-molecule targeting of an intractable protein surface
About this item
Full title
Author / Creator
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS) , Shigdel, Uddhav K. , Lee, Seung-Joo , Sowa, Mathew E. , Bowman, Brian R. , Robison, Keith , Zhou, Minyun , Pua, Khian Hong , Stiles, Dylan T. , Blodgett, Joshua A. V. , Udwary, Daniel W. , Rajczewski, Andrew T. , Mann, Alan S. , Mostafavi, Siavash , Hardy, Tara , Arya, Sukrat , Weng, Zhigang , Stewart, Michelle , Kenyon, Kyle , Morgenstern, Jay P. , Pan, Ende , Gray, Daniel C. , Pollock, Roy M. , Fry, Andrew M. , Klausner, Richard D. , Townson, Sharon A. and Verdine, Gregory L.
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
The vast majority of intracellular protein targets are refractory toward small-molecule therapeutic engagement, and additional therapeutic modalities are needed to overcome this deficiency. Here, the identification and characterization of a natural product, WDB002, reveals a therapeutic modality that dramatically expands the currently accepted limi...
Alternative Titles
Full title
Genomic discovery of an evolutionarily programmed modality for small-molecule targeting of an intractable protein surface
Authors, Artists and Contributors
Author / Creator
Shigdel, Uddhav K.
Lee, Seung-Joo
Sowa, Mathew E.
Bowman, Brian R.
Robison, Keith
Zhou, Minyun
Pua, Khian Hong
Stiles, Dylan T.
Blodgett, Joshua A. V.
Udwary, Daniel W.
Rajczewski, Andrew T.
Mann, Alan S.
Mostafavi, Siavash
Hardy, Tara
Arya, Sukrat
Weng, Zhigang
Stewart, Michelle
Kenyon, Kyle
Morgenstern, Jay P.
Pan, Ende
Gray, Daniel C.
Pollock, Roy M.
Fry, Andrew M.
Klausner, Richard D.
Townson, Sharon A.
Verdine, Gregory L.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7382241
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7382241
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.2006560117
