Increasing FIM2/3 antigen-content improves efficacy of Bordetella pertussis vaccines in mice in vivo...
Increasing FIM2/3 antigen-content improves efficacy of Bordetella pertussis vaccines in mice in vivo without altering vaccine-induced human reactogenicity biomarkers in vitro
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Netherlands: Elsevier Ltd
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Language
English
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Publisher
Netherlands: Elsevier Ltd
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Contents
Highlights•Pertussis resurgence suggests low efficacy of existing vaccines. •New strategies to improve aP vaccines efficacy are urgently needed. •Pertactin-negative isolates have the potential to negatively impact aP efficacy. •Extra FIM2/3 reduces lung colonization and enhances aP efficacy in murine model. •Additional amounts of FIM2/3 do not chan...
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Full title
Increasing FIM2/3 antigen-content improves efficacy of Bordetella pertussis vaccines in mice in vivo without altering vaccine-induced human reactogenicity biomarkers in vitro
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7385666
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7385666
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ISSN
0264-410X
E-ISSN
1873-2518
DOI
10.1016/j.vaccine.2018.11.028
