Altered mechanisms of genital development identified through integration of DNA methylation and geno...
Altered mechanisms of genital development identified through integration of DNA methylation and genomic measures in hypospadias
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Author / Creator
Richard, Melissa A. , Sok, Pagna , Canon, Stephen , Nembhard, Wendy N. , Brown, Austin L. , Peckham-Gregory, Erin C. , Ton, Minh , Ehli, Erik A. , Kallsen, Noah A. , Peyton, Shanna A. , Davies, Gareth E. , Patel, Ashay , Zamilpa, Ismael , Hobbs, Charlotte A. , Scheurer, Michael E. and Lupo, Philip J.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Hypospadias is a common birth defect where the urethral opening forms on the ventral side of the penis. We performed integrative methylomic, genomic, and transcriptomic analyses to characterize sites of DNA methylation that influence genital development. In case–control and case-only epigenome-wide association studies (EWAS) of preputial tissue we...
Alternative Titles
Full title
Altered mechanisms of genital development identified through integration of DNA methylation and genomic measures in hypospadias
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7391634
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7391634
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-020-69725-1
