The pseudo-caspase FLIP(L) regulates cell fate following p53 activation
The pseudo-caspase FLIP(L) regulates cell fate following p53 activation
About this item
Full title
Author / Creator
Lees, Andrea , McIntyre, Alexander J. , Crawford, Nyree T. , Falcone, Fiammetta , McCann, Christopher , Holohan, Caitriona , Quinn, Gerard P. , Roberts, Jamie Z. , Sessler, Tamas , Gallagher, Peter F. , Gregg, Gemma M. A. , McAllister, Katherine , McLaughlin, Kirsty M. , Allen, Wendy L. , Egan, Laurence J. , Ryan, Aideen E. , Labonte-Wilson, Melissa J. , Dunne, Philip D. , Wappett, Mark , Coyle, Vicky M. , Johnston, Patrick G. , Kerr, Emma M. , Longley, Daniel B. and McDade, Simon S.
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
p53 is the most frequently mutated, well-studied tumor-suppressor gene, yet the molecular basis of the switch from p53-induced cellcycle arrest to apoptosis remains poorly understood. Using a combination of transcriptomics and functional genomics, we unexpectedly identified a nodal role for the caspase-8 paralog and only human pseudo-caspase, FLIP(...
Alternative Titles
Full title
The pseudo-caspase FLIP(L) regulates cell fate following p53 activation
Authors, Artists and Contributors
Author / Creator
McIntyre, Alexander J.
Crawford, Nyree T.
Falcone, Fiammetta
McCann, Christopher
Holohan, Caitriona
Quinn, Gerard P.
Roberts, Jamie Z.
Sessler, Tamas
Gallagher, Peter F.
Gregg, Gemma M. A.
McAllister, Katherine
McLaughlin, Kirsty M.
Allen, Wendy L.
Egan, Laurence J.
Ryan, Aideen E.
Labonte-Wilson, Melissa J.
Dunne, Philip D.
Wappett, Mark
Coyle, Vicky M.
Johnston, Patrick G.
Kerr, Emma M.
Longley, Daniel B.
McDade, Simon S.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7395556
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7395556
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.2001520117
