Large-scale proteomic analysis of Alzheimer’s disease brain and cerebrospinal fluid reveals early ch...
Large-scale proteomic analysis of Alzheimer’s disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation
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Author / Creator
Pacific Northwest National Laboratory (PNNL), Richland, WA (United States) , Johnson, Erik C. B. , Dammer, Eric B. , Duong, Duc M. , Ping, Lingyan , Zhou, Maotian , Yin, Luming , Higginbotham, Lenora A. , Guajardo, Andrew , White, Bartholomew , Troncoso, Juan C. , Thambisetty, Madhav , Montine, Thomas J. , Lee, Edward B. , Trojanowski, John Q. , Beach, Thomas G. , Reiman, Eric M. , Haroutunian, Vahram , Wang, Minghui , Schadt, Eric , Zhang, Bin , Dickson, Dennis W. , Ertekin-Taner, Nilüfer , Golde, Todd E. , Petyuk, Vladislav A. , De Jager, Philip L. , Bennett, David A. , Wingo, Thomas S. , Rangaraju, Srikant , Hajjar, Ihab , Shulman, Joshua M. , Lah, James J. , Levey, Allan I. and Seyfried, Nicholas T.
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publication information
Publisher
New York: Nature Publishing Group US
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More information
Scope and Contents
Contents
Our understanding of Alzheimer’s disease (AD) pathophysiology remains incomplete. Here we used quantitative mass spectrometry and coexpression network analysis to conduct the largest proteomic study thus far on AD. A protein network module linked to sugar metabolism emerged as one of the modules most significantly associated with AD pathology and c...
Alternative Titles
Full title
Large-scale proteomic analysis of Alzheimer’s disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation
Authors, Artists and Contributors
Author / Creator
Johnson, Erik C. B.
Dammer, Eric B.
Duong, Duc M.
Ping, Lingyan
Zhou, Maotian
Yin, Luming
Higginbotham, Lenora A.
Guajardo, Andrew
White, Bartholomew
Troncoso, Juan C.
Thambisetty, Madhav
Montine, Thomas J.
Lee, Edward B.
Trojanowski, John Q.
Beach, Thomas G.
Reiman, Eric M.
Haroutunian, Vahram
Wang, Minghui
Schadt, Eric
Zhang, Bin
Dickson, Dennis W.
Ertekin-Taner, Nilüfer
Golde, Todd E.
Petyuk, Vladislav A.
De Jager, Philip L.
Bennett, David A.
Wingo, Thomas S.
Rangaraju, Srikant
Hajjar, Ihab
Shulman, Joshua M.
Lah, James J.
Levey, Allan I.
Seyfried, Nicholas T.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7405761
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7405761
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/s41591-020-0815-6
