PGE1 and PGA1 bind to Nurr1 and activate its transcriptional function
PGE1 and PGA1 bind to Nurr1 and activate its transcriptional function
About this item
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Author / Creator
Rajan, Sreekanth , Jang, Yongwoo , Kim, Chun-Hyung , Kim, Woori , Toh, Hui Ting , Jeon, Jeha , Song, Bin , Serra, Aida , Lescar, Julien , Yoo, Jun Yeob , Beldar, Serap , Ye, Hong , Kang, Congbao , Liu, Xue-Wei , Feitosa, Melissa , Kim, Yeahan , Hwang, Dabin , Goh, Geraldine , Lim, Kah-Leong , Park, Hye Min , Lee, Choong Hwan , Oh, Sungwhan F. , Petsko, Gregory A. , Yoon, Ho Sup and Kim, Kwang-Soo
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publication information
Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
The orphan nuclear receptor Nurr1 is critical for the development, maintenance and protection of midbrain dopaminergic (mDA) neurons. Here we show that prostaglandin E1 (PGE1) and its dehydrated metabolite, PGA1, directly interact with the ligand-binding domain (LBD) of Nurr1 and stimulate its transcriptional function. We also report the crystallog...
Alternative Titles
Full title
PGE1 and PGA1 bind to Nurr1 and activate its transcriptional function
Authors, Artists and Contributors
Author / Creator
Jang, Yongwoo
Kim, Chun-Hyung
Kim, Woori
Toh, Hui Ting
Jeon, Jeha
Song, Bin
Serra, Aida
Lescar, Julien
Yoo, Jun Yeob
Beldar, Serap
Ye, Hong
Kang, Congbao
Liu, Xue-Wei
Feitosa, Melissa
Kim, Yeahan
Hwang, Dabin
Goh, Geraldine
Lim, Kah-Leong
Park, Hye Min
Lee, Choong Hwan
Oh, Sungwhan F.
Petsko, Gregory A.
Yoon, Ho Sup
Kim, Kwang-Soo
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7405943
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7405943
Other Identifiers
ISSN
1552-4450,1552-4469
E-ISSN
1552-4469
DOI
10.1038/s41589-020-0553-6
