Genetically detoxified pertussis toxin displays near identical structure to its wild-type and exhibi...
Genetically detoxified pertussis toxin displays near identical structure to its wild-type and exhibits robust immunogenicity
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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The mutant gdPT R9K/E129G is a genetically detoxified variant of the pertussis toxin (PTx) and represents an attractive candidate for the development of improved pertussis vaccines. The impact of the mutations on the overall protein structure and its immunogenicity has remained elusive. Here we present the crystal structure of gdPT and show that it...
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Genetically detoxified pertussis toxin displays near identical structure to its wild-type and exhibits robust immunogenicity
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7406505
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7406505
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ISSN
2399-3642
E-ISSN
2399-3642
DOI
10.1038/s42003-020-01153-3
