KN3014, a piperidine-containing small compound, inhibits auto-secretion of IL-1β from PBMCs in a pat...
KN3014, a piperidine-containing small compound, inhibits auto-secretion of IL-1β from PBMCs in a patient with Muckle–Wells syndrome
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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NLRP3, an intracellular pattern recognition receptor, recognizes numerous pathogens and/or its own damage-associated molecules, and forms complexes with the adaptor protein ASC. These complexes constitute the NLRP3 inflammasome, a platform for processing interleukin (IL)-1β and/or IL-18. Several NLRP3 mutations result in constitutive activation of...
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Full title
KN3014, a piperidine-containing small compound, inhibits auto-secretion of IL-1β from PBMCs in a patient with Muckle–Wells syndrome
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7419506
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7419506
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-020-70513-0
