Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia
Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia
About this item
Full title
Author / Creator
Zenatti, Priscila P , Ribeiro, Daniel , Li, Wenqing , Zuurbier, Linda , Silva, Milene C , Paganin, Maddalena , Tritapoe, Julia , Hixon, Julie A , Silveira, André B , Cardoso, Bruno A , Sarmento, Leonor M , Correia, Nádia , Toribio, Maria L , Kobarg, Jörg , Horstmann, Martin , Pieters, Rob , Brandalise, Silvia R , Ferrando, Adolfo A , Meijerink, Jules P , Durum, Scott K , Yunes, J Andrés and Barata, João T
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
João Barata and colleagues identify somatic gain-of-function
IL7R
mutations in childhood T-cell acute lymphoblastic leukemia. The mutations result in constitutive receptor activation, implicating the IL-7R pathway as a potential therapeutic target in a subset of T-ALL cases.
Interleukin 7 (IL-7) and its receptor, formed by IL-7Rα (encoded...
Alternative Titles
Full title
Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia
Authors, Artists and Contributors
Author / Creator
Ribeiro, Daniel
Li, Wenqing
Zuurbier, Linda
Silva, Milene C
Paganin, Maddalena
Tritapoe, Julia
Hixon, Julie A
Silveira, André B
Cardoso, Bruno A
Sarmento, Leonor M
Correia, Nádia
Toribio, Maria L
Kobarg, Jörg
Horstmann, Martin
Pieters, Rob
Brandalise, Silvia R
Ferrando, Adolfo A
Meijerink, Jules P
Durum, Scott K
Yunes, J Andrés
Barata, João T
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7424552
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7424552
Other Identifiers
ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/ng.924
