ELABELA attenuates deoxycorticosterone acetate/salt-induced hypertension and renal injury by inhibit...
ELABELA attenuates deoxycorticosterone acetate/salt-induced hypertension and renal injury by inhibition of NADPH oxidase/ROS/NLRP3 inflammasome pathway
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Author / Creator
Chen, Zhida , Wu, Chunying , Liu, Yuting , Li, Haonan , Zhu, Yeyan , Huang, Cailing , Lin, Huangbo , Qiao, Qiao , Huang, Mengming , Zhu, Qing and Wang, Lei
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
ELABELA (ELA), a 32-residue hormone peptide abundantly expressed in adult kidneys, has been identified as a novel endogenous ligand for APJ/Apelin receptor. The aim of this study was to investigate the role of ELA in deoxycorticosterone acetate (DOCA)/salt-induced hypertension and further explore the underlying mechanism. In DOCA/salt-treated rats,...
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Full title
ELABELA attenuates deoxycorticosterone acetate/salt-induced hypertension and renal injury by inhibition of NADPH oxidase/ROS/NLRP3 inflammasome pathway
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7443189
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7443189
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ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/s41419-020-02912-0
