In-cell destabilization of a homodimeric protein complex detected by DEER spectroscopy
In-cell destabilization of a homodimeric protein complex detected by DEER spectroscopy
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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The complexity of the cellular medium can affect proteins’ properties, and, therefore, in-cell characterization of proteins is essential. We explored the stability and conformation of the first baculoviral IAP repeat (BIR) domain of X chromosome-linked inhibitor of apoptosis (XIAP), BIR1, as a model for a homodimer protein in human HeLa cells. We e...
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In-cell destabilization of a homodimeric protein complex detected by DEER spectroscopy
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7456071
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7456071
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.2005779117
