The histone methyltransferase DOT1L prevents antigen-independent differentiation and safeguards epig...
The histone methyltransferase DOT1L prevents antigen-independent differentiation and safeguards epigenetic identity of CD8⁺ T cells
About this item
Full title
Author / Creator
Kwesi-Maliepaard, Eliza Mari , Aslam, Muhammad Assad , Alemdehy, Mir Farshid , van den Brand, Teun , McLean, Chelsea , Vlaming, Hanneke , van Welsem, Tibor , Korthout, Tessy , Lancini, Cesare , Hendriks, Sjoerd , Ahrends, Tomasz , van Dinther, Dieke , den Haan, Joke M. M. , Borst, Jannie , de Wit, Elzo , van Leeuwen, Fred and Jacobs, Heinz
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
Cytotoxic T cell differentiation is guided by epigenome adaptations, but how epigenetic mechanisms control lymphocyte development has not been well defined. Here we show that the histone methyltransferase DOT1L, which marks the nucleosome core on active genes, safeguards normal differentiation of CD8⁺r T cells. T cell-specific ablation of Dot1L res...
Alternative Titles
Full title
The histone methyltransferase DOT1L prevents antigen-independent differentiation and safeguards epigenetic identity of CD8⁺ T cells
Authors, Artists and Contributors
Author / Creator
Aslam, Muhammad Assad
Alemdehy, Mir Farshid
van den Brand, Teun
McLean, Chelsea
Vlaming, Hanneke
van Welsem, Tibor
Korthout, Tessy
Lancini, Cesare
Hendriks, Sjoerd
Ahrends, Tomasz
van Dinther, Dieke
den Haan, Joke M. M.
Borst, Jannie
de Wit, Elzo
van Leeuwen, Fred
Jacobs, Heinz
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7456197
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7456197
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1920372117
