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Peripheral host T cells survive hematopoietic stem cell transplantation and promote graft-versus-hos...

Peripheral host T cells survive hematopoietic stem cell transplantation and promote graft-versus-hos...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7456221

Peripheral host T cells survive hematopoietic stem cell transplantation and promote graft-versus-host disease

About this item

Full title

Peripheral host T cells survive hematopoietic stem cell transplantation and promote graft-versus-host disease

Publisher

United States: American Society for Clinical Investigation

Journal title

The Journal of clinical investigation, 2020-09, Vol.130 (9), p.4624-4636

Language

English

Formats

Publication information

Publisher

United States: American Society for Clinical Investigation

More information

Scope and Contents

Contents

Graft-versus-host disease (GVHD) is a major cause of morbidity and mortality in hematopoietic stem cell transplantation (HSCT). Donor T cells are key mediators in pathogenesis, but a contribution from host T cells has not been explored, as conditioning regimens are believed to deplete host T cells. To evaluate a potential role for host T cells in G...

Alternative Titles

Full title

Peripheral host T cells survive hematopoietic stem cell transplantation and promote graft-versus-host disease

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7456221

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7456221

Other Identifiers

ISSN

0021-9738

E-ISSN

1558-8238

DOI

10.1172/JCI129965

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