Bruton’s tyrosine kinase inhibition effectively protects against human IgE-mediated anaphylaxis
Bruton’s tyrosine kinase inhibition effectively protects against human IgE-mediated anaphylaxis
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Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
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Publisher
United States: American Society for Clinical Investigation
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Contents
No known therapies can prevent anaphylaxis. Bruton's tyrosine kinase (BTK) is an enzyme thought to be essential for high-affinity IgE receptor (FcεRI) signaling in human cells. We tested the hypothesis that FDA-approved BTK inhibitors (BTKis) would prevent IgE-mediated responses including anaphylaxis. We showed that irreversible BTKis broadly preve...
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Full title
Bruton’s tyrosine kinase inhibition effectively protects against human IgE-mediated anaphylaxis
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7456252
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7456252
Other Identifiers
ISSN
0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI138448
