Trastuzumab Deruxtecan in Previously Treated HER2-Positive Breast Cancer
Trastuzumab Deruxtecan in Previously Treated HER2-Positive Breast Cancer
About this item
Full title
Author / Creator
Modi, Shanu , Saura, Cristina , Yamashita, Toshinari , Park, Yeon Hee , Kim, Sung-Bae , Tamura, Kenji , Andre, Fabrice , Iwata, Hiroji , Ito, Yoshinori , Tsurutani, Junji , Sohn, Joohyuk , Denduluri, Neelima , Perrin, Christophe , Aogi, Kenjiro , Tokunaga, Eriko , Im, Seock-Ah , Lee, Keun Seok , Hurvitz, Sara A , Cortes, Javier , Lee, Caleb , Chen, Shuquan , Zhang, Lin , Shahidi, Javad , Yver, Antoine , Krop, Ian and DESTINY-Breast01 Investigators
Publisher
United States: Massachusetts Medical Society
Journal title
Language
English
Formats
Publication information
Publisher
United States: Massachusetts Medical Society
Subjects
More information
Scope and Contents
Contents
In this single-group, phase 2 study, the use of trastuzumab deruxtecan resulted in a response in 60% of women with HER2-positive advanced breast cancer who had received a median of six previous lines of therapy. The drug was associated with myelosuppression and gastrointestinal toxicity; interstitial lung disease was reported in 13.6% of the patien...
Alternative Titles
Full title
Trastuzumab Deruxtecan in Previously Treated HER2-Positive Breast Cancer
Authors, Artists and Contributors
Author / Creator
Saura, Cristina
Yamashita, Toshinari
Park, Yeon Hee
Kim, Sung-Bae
Tamura, Kenji
Andre, Fabrice
Iwata, Hiroji
Ito, Yoshinori
Tsurutani, Junji
Sohn, Joohyuk
Denduluri, Neelima
Perrin, Christophe
Aogi, Kenjiro
Tokunaga, Eriko
Im, Seock-Ah
Lee, Keun Seok
Hurvitz, Sara A
Cortes, Javier
Lee, Caleb
Chen, Shuquan
Zhang, Lin
Shahidi, Javad
Yver, Antoine
Krop, Ian
DESTINY-Breast01 Investigators
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7458671
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7458671
Other Identifiers
ISSN
0028-4793
E-ISSN
1533-4406
DOI
10.1056/NEJMoa1914510
