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Endophilin A2 regulates calcium-activated chloride channel activity via selective autophagy-mediated...

Endophilin A2 regulates calcium-activated chloride channel activity via selective autophagy-mediated...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7470808

Endophilin A2 regulates calcium-activated chloride channel activity via selective autophagy-mediated TMEM16A degradation

About this item

Full title

Endophilin A2 regulates calcium-activated chloride channel activity via selective autophagy-mediated TMEM16A degradation

Publisher

Singapore: Springer Singapore

Journal title

Acta pharmacologica Sinica, 2020-02, Vol.41 (2), p.208-217

Language

English

Formats

Publication information

Publisher

Singapore: Springer Singapore

More information

Scope and Contents

Contents

TMEM16A Ca
2+
-activated chloride channel (CaCC) plays an essential role in vascular homeostasis. In this study we investigated the molecular mechanisms underlying downregulation of TMEM16A CaCC activity during hypertension. In cultured basilar artery smooth muscle cells (BASMCs) isolated from 2k2c renohypertesive rats, treatment with angiote...

Alternative Titles

Full title

Endophilin A2 regulates calcium-activated chloride channel activity via selective autophagy-mediated TMEM16A degradation

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7470808

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7470808

Other Identifiers

ISSN

1671-4083

E-ISSN

1745-7254

DOI

10.1038/s41401-019-0298-5

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