Simple binding of protein kinase A prior to phosphorylation allows CFTR anion channels to be opened...
Simple binding of protein kinase A prior to phosphorylation allows CFTR anion channels to be opened by nucleotides
About this item
Full title
Author / Creator
Publisher
Washington: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
Washington: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) anion channel is essential for epithelial salt–water balance. CFTR mutations cause cystic fibrosis, a lethal incurable disease. In cells CFTR is activated through the cAMP signaling pathway, overstimulation of which during cholera leads to CFTR-mediated intestinal salt–water loss. Chann...
Alternative Titles
Full title
Simple binding of protein kinase A prior to phosphorylation allows CFTR anion channels to be opened by nucleotides
Authors, Artists and Contributors
Author / Creator
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7474675
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7474675
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.2007910117
