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Coupled transmembrane mechanisms control MCU-mediated mitochondrial Ca2+ uptake

Coupled transmembrane mechanisms control MCU-mediated mitochondrial Ca2+ uptake

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7474680

Coupled transmembrane mechanisms control MCU-mediated mitochondrial Ca2+ uptake

About this item

Full title

Coupled transmembrane mechanisms control MCU-mediated mitochondrial Ca2+ uptake

Publisher

Washington: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2020-09, Vol.117 (35), p.21731-21739

Language

English

Formats

Publication information

Publisher

Washington: National Academy of Sciences

More information

Scope and Contents

Contents

Ca2+ uptake by mitochondria regulates bioenergetics, apoptosis, and Ca2+ signaling. The primary pathway for mitochondrial Ca2+ uptake is the mitochondrial calcium uniporter (MCU), a Ca2+-selective ion channel in the inner mitochondrial membrane. MCU-mediated Ca2+ uptake is driven by the sizable inner-membrane potential generated by the electron-tra...

Alternative Titles

Full title

Coupled transmembrane mechanisms control MCU-mediated mitochondrial Ca2+ uptake

Authors, Artists and Contributors

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7474680

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7474680

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

DOI

10.1073/pnas.2005976117

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