Coupled transmembrane mechanisms control MCU-mediated mitochondrial Ca2+ uptake
Coupled transmembrane mechanisms control MCU-mediated mitochondrial Ca2+ uptake
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Publisher
Washington: National Academy of Sciences
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Language
English
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Washington: National Academy of Sciences
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Contents
Ca2+ uptake by mitochondria regulates bioenergetics, apoptosis, and Ca2+ signaling. The primary pathway for mitochondrial Ca2+ uptake is the mitochondrial calcium uniporter (MCU), a Ca2+-selective ion channel in the inner mitochondrial membrane. MCU-mediated Ca2+ uptake is driven by the sizable inner-membrane potential generated by the electron-tra...
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Full title
Coupled transmembrane mechanisms control MCU-mediated mitochondrial Ca2+ uptake
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7474680
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7474680
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.2005976117